Stem Cell Reports will publish a special issue of the journal with a focus on chromatin and nuclear architecture.
Chromatin, comprised of DNA, histones, and additional structural proteins, is the fundamental unit of life. Essentially all cellular processes are governed by changes in chromatin structure, which, in turn, regulates gene expression. Such changes are particularly pertinent in stem cells, which maintain potency on the one hand, but undergo massive changes upon differentiation on the other.
- Generating a Totipotent Embryo through Rebooting the Epigenome
Wei Xie, Tsinghua University
- Nucleolar Chromatin in Stem Cells
Raffaella Santoro, University of Zurich (UZH)
- Dynamic 3D Chromatin Reorganization during Establishment and Maintenance of Pluripotency
Effie Apostolou, Weill Cornell Medicine, Division of Hematology & Medical Oncology, Sandra and Edward Meyer Cancer Center
- Histone Modifications in Stem Cell Development and Their Clinical Implications
Axel Imhof, Ludwig-Maximilians-University of Munich
- Chromatin Associated Membraneless Organelles in Regulation of Cellular Differentiation
Micah Drukker, Helmholtz Center Munich
This special issue is scheduled to publish in November 2020.